Paradigm PCDx

Start getting better results, faster

The most clinically actionable testing available today to help deliver precision medicine.
Order PCDx

Paradigm PCDx

Start getting better results, faster

PCDx can help identify the best cancer treatment options for you today.
Order PCDx

Paradigm PCDx

Start getting better results, faster

Published Prospective Clinical Data.
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Paradigm’s 5000x average depth of coverage ensures confidence in that both positive and negative calls are correct. This level of assurance is unique to Paradigm.


PCDx assesses the most clinically actionable genomic variations in cancer, including: mutations, copy number variations, mRNA expression and protein expression.


Paradigm promises a clinically relevant turnaround time. Customers can expect 5 business days from sample receipt to reporting ensures continuity of clinical care.

Comprehensive test results, in record time.

Learn more about PCDx
Copy Number Variations

CNVs are alterations of the DNA of the cancer genome that result in the cell having abnormal copies of one or more sections of the DNA. These alterations can have a significant impact on response to therapy (e.g., HER2).

mRNA Expression

Gene expression is the process by which information from a gene is used in the synthesis of a functional protein. Sequencing-based mRNA analysis enables the significant multiplexing of biomarker targets (e.g., ER, ERCC1).

Fusions / Isoforms

Fusions and isoforms are rearrangements of genes or the exons within genes that result in abnormal gene expression or function. These alterations can have significant impact on therapy, particularly in non-small cell lung cancers. PCDx precisely identifies the exact breakpoints with single-base resolution.

Protein Expression

Changes in the protein expression as measured by IHC has been utilized for many years as the gold-standard to quantitate the actual translation of altered gene products. Our ability to interrogate key protein markers (e.g. PD-L1, HER2, AR, MGMT, TOP1) provides insights on potential response to both cytotoxic agents as well as emerging clinical trials.

DNA Mutations

Changes in the DNA sequence of chromosomes, including insertions, deletions and base substitutions. Somatic mutation analysis has become standard of practice for solid tumors in order to identify therapeutic sensitizing and resistance mutations (e.g., EGFR, KRAS, BRAF).

Results in 5 days.

PCDx promises a clinically relevant turnaround time of 5 business days from sample receipt to reporting.
Order PCDx
Day 1

Sample is received and pathology confirms initial diagnosis with H&E.

Day 2

Tumor DNA & RNA are extracted, purified and quantified.

Day 3

DNA & RNA library creation.

Day 4

Sequencing and IHC analysis.

Day 5

Clinical interpretation of results, quality assurance performed and clinical report delivered.

How to order PCDx

Receive your PCDx test results in 3 simple steps. Follow the instructions below to start the process.
Order PCDx


Fill out the requisition form

The PDF test requisition form can be completed digitally, within Adobe Acrobat.

Download the form


Send us the form via fax/email

For your convenience, the requisition form can be sent to Paradigm via email or fax.

View ordering information


Mail the tissue sample

Please follow our preparation & shipping guidelines to ensure quality DNA/RNA analysis.

View tissue prep guidelines

Receive your results.

Results will identify all actionable classes of genomic alterations in cancer-related genes.

Learn about PCDx